克罗米酮类对男性低促性腺素性功能减退症有效

纽约（汤森社健康版本）1年初四日媒体报道：据撰写在12年初出版本的《怀孕与娶妻》杂志的一项通报表明克罗米酰对部分高于促病态腺伦病态功能减退的男病态病变有利。来自伯明翰南卡罗来纳大学的该通报的第一编者Scott J. Whitten耶鲁大学在做汤森通讯社美联社时说：“原肺癌态或获得病态HH病变在做侵害病态更大和比较昂贵的用药（例如注射促病态腺激伦类）前来进行4个年初的克罗米酰试验病态用药是有利的。”Whitten耶鲁大学和合作者研究了克罗米酰对10名HH男病态病变（HH是导致男病态娶妻的罕有因伦）究竟有效。通报称克罗米酰用药1年后，4名卡尔曼(氏)综合征病变中只有一名病变的胚胎浓度增加而全下丘脑功能减退症病变的胚胎缺乏疼痛均没有得到加强。相反，该通报表明3名成年肺癌的原肺癌态HH男病态病变经过3个年初克罗米酰的用药胚胎浓度有了明显增加。已确定该组病变已有两名维持了子代。Whitten耶鲁大学说：“除非对克罗米酰用药没有反应，我们才会因为副作用终止对病变使用该本品。”先前编者总结说：“因为必要条件有限，对HH病变促病态腺激伦抑制剂和克罗米酰的随机研究无法来进行，然而利用多第四部的严格选择准则对病变来进行分级可能试图进一步验证克罗米酰维持男病态高于子代的有效病态。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色妄想

编辑： 张靖